Movie poster of "Monsters vs. Aliens"

Reese Witherspoon is to play a giant in a new animated battle movie.

The Oscar-winning actress will team up with Hugh Laurie, Seth Rogen and Kiefer Sutherland, among others, to voice quirky characters in Dreamworks' upcoming film Monsters vs. Aliens.

Witherspoon's character, Susan Murphy, becomes a 50-foot monster, dubbed Ginormia, after she's hit by a meteor from outer space.

She's captured by the U.S. military and taken to a top-secret compound, where other 'monsters' are kept.

These include the insect-headed Dr. Cockroach (Laurie) and half-ape/half-fish Missing Link (Will Arnett). Sutherland will voice the aptly named General W.R. Monger.

The monsters team up to attack invading aliens.